Protective effects of Naoxintong capsule alone and in combination with ticagrelor and atorvastatin in rats with Qi deficiency and blood stasis syndrome

Autor: Yan He, Qing-wei Lin, Zenghao Yan, Zhang Weijian, Hong Liu, Yonggang Wang, Peibo Li, Weiwei Su, Hao Wu, Hongliang Yao
Rok vydání: 2020
Předmět:
Male
Ticagrelor
Atorvastatin
Pharmaceutical Science
Coronary Disease
Traditional Chinese medicine
Blood stasis
Pharmacology
medicine.disease_cause
030226 pharmacology & pharmacy
01 natural sciences
immune response
Rats
Sprague-Dawley
0302 clinical medicine
endothelial function
Drug Discovery
oxidative stress
General Medicine
Molecular Medicine
Drug Therapy
Combination
medicine.symptom
Research Article
medicine.drug
Cardiotonic Agents
Qi
drug combination
Inflammation
RM1-950
03 medical and health sciences
Immune system
medicine
Animals
coronary heart disease
Dose-Response Relationship
Drug
business.industry
Capsule
Rats
0104 chemical sciences
Disease Models
Animal
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
inflammation
traditional chinese medicine
Therapeutics. Pharmacology
business
Oxidative stress
Drugs
Chinese Herbal
Zdroj: Pharmaceutical Biology, Vol 58, Iss 1, Pp 1006-1022 (2020)
Pharmaceutical Biology
article-version (VoR) Version of Record
ISSN: 1744-5116
1388-0209
DOI: 10.1080/13880209.2020.1821066
Popis: Context Naoxintong Capsule (NXT), a Chinese medicine, has been widely used for the treatment of coronary heart disease (CHD) in clinics. Objective This study evaluated the cardioprotective effects of NXT alone and in combination with ticagrelor (TIC) and atorvastatin (ATO). Materials and methods Qi deficiency and blood stasis rats were established by 8 weeks high fat diet feeding and 16 days exhaustive swimming and randomly divided into seven groups, that is, NXT (250, 500 and 1000 mg/kg/d), TIC (20 mg/kg/d), ATO (8 mg/kg/d), NXT (500 mg/kg/d)+TIC (20 mg/kg/d) and NXT (500 mg/kg/d)+ATO (8 mg/kg/d) group, with oral administration for 12 weeks. The contents of TC, TG, LDL-C, HDL-C, IL-1β, IL-6, IL-8, TNF-α, AST, ALT, SOD, MDA, CK-MB, LDH, TXA2, PGI2, IgA, IgG, IgM and C3 in serum were measured. Results NXT + TIC group was significantly superior to the TIC group in decreasing the levels of TC (4.34 vs. 5.54), TG (3.37 vs. 4.66), LDL-C (1.21 vs. 1.35), LDH (4919.71vs. 5367.19) and elevating SOD level (248.54 vs. 192.04). NXT + ATO group was significantly superior to the ATO group in decreasing the levels of AST (195.931 vs. 241.63), ALT (71.26 vs. 83.16), LDH (4690.05 vs. 5285.82), TXA2 (133.73 vs. 158.67), IgG (8.08 vs. 9.80), C3 (2.03 vs. 2.35) and elevating the levels of HDL-C (1.19 vs. 0.91), SOD (241.91vs. 209.49). Conclusions The present findings demonstrate that the combined use of NXT with TIC and ATO had better integrated regulating effects than TIC and ATO, respectively. The mechanism of action requires further research.
Databáze: OpenAIRE
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