Clinical and Molecular Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Infections in Metro Detroit: Early Dominance of the ST-131 Clone

Autor:	Pansy Awasthy, Emily T. Martin, Dror Marchaim, Richard Evans, John P. Mills, Elizabeth Salzman, Keith S Kaye, Kayoko Hayakawa, Jason M. Pogue, Madiha Salim
Rok vydání:	2020
Předmět:	0301 basic medicine Microbiology (medical) medicine.medical_treatment 030106 microbiology Infectious and parasitic diseases RC109-216 Clinical epidemiology medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine Escherichia coli medicine 030212 general & internal medicine Typing Dominance (genetics) Molecular epidemiology business.industry Brief Report Sequence typing Mortality rate Extended spectrum beta-lactamase Infectious Diseases Median time Beta-lactamase business
Zdroj:	Infectious Diseases and Therapy Infectious Diseases and Therapy, Vol 9, Iss 3, Pp 683-690 (2020)
ISSN:	2193-6382 2193-8229
Popis:	Introduction Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli infections have become endemic worldwide. We aimed to describe the molecular and clinical epidemiology of ESBL-producing E. coli infections during a period of rising global prevalence. Methods Three hundred sixty-nine consecutive ESBL-producing E. coli infections in Detroit from 2010–2011 were analyzed. Sequence typing (ST) and CH typing were performed. Clinical characteristics and outcomes were compared between patients infected with ST131 and non-ST131 isolates. Results Ninety-six percent of isolates were ST 131, and 78.6% of ST 131 isolates produced blaCTX-M-15. Median time to effective therapy was 48 h vs. 35 h (P = 0.38) in the ST131 vs. non-ST131 groups. Ninety-day mortality rates (8% vs. 8%, P = 1.0) were similar between the two groups. Conclusion blaCTX-M-15 ST131 E. coli predominated in Detroit during an early period of global ST131 dissemination. Patients with ST131 E. coli infections had similar clinical outcomes to those with non-ST131 E. coli infections. Electronic supplementary material The online version of this article (10.1007/s40121-020-00321-6) contains supplementary material, which is available to authorized users.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f21dd639674f0a3a014d23d0968409 https://doi.org/10.1007/s40121-020-00321-6 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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