Laminins: Structure and genetic regulation
| Autor: | Neil Smyth, Mats Paulsson, Patrick Tunggal, Mark-Christoph Ott |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Integrins
Histology Molecular Sequence Data Integrin Morphogenesis Biology Basement Membrane Cell surface receptor Laminin Extracellular Animals Humans Protein Isoforms Amino Acid Sequence Dystroglycans Receptor Instrumentation Membrane Glycoproteins Alternative splicing Cell biology Alternative Splicing Cytoskeletal Proteins Medical Laboratory Technology Gene Expression Regulation biology.protein Anatomy Function (biology) |
| Zdroj: | Microscopy Research and Technique. 51:214-227 |
| ISSN: | 1097-0029 1059-910X |
| Popis: | The laminins form a large family of modular proteins found in basement membranes, but also elsewhere. They function as structural components and are essential for morphogenesis, but in addition interact with cell surface receptors such as integrins and α-dystroglycan. By virtue of their receptor interactions, they initiate intracellular signalling events that regulate cellular organization and differentiation. The many interactions of laminins are mediated by binding sites, often contributed by single domains, which may differ between different forms of laminin. In the present article, we describe how the diversity of laminins and the genetic regulation of the expression of different laminin forms lead to the formation of extracellular matrices with variable laminin composition and thereby different biological properties. Microsc. Res. Tech. 51:214–227, 2000. © 2000 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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