Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Autor: Martin Kerschensteiner, Chris Lauber, Lisa Ann Gerdes, Horst Penkert, Reinhard Hohlfeld, Dirk Fitzner, Tania Kümpfel, Mathias J. Gerl, Markus Damm, Mikael Simons, Andrea Flierl-Hecht, Christian Klose
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Brief Communication
blood [Phosphatidylethanolamines]
Cohort Studies
03 medical and health sciences
blood [Phospholipids]
0302 clinical medicine
Internal medicine
Lipidomics
medicine
Diseases in Twins
Humans
ddc:610
Phospholipids
blood [Biomarkers]
business.industry
General Neuroscience
Multiple sclerosis
Phosphatidylethanolamines
Shotgun lipidomics
Lipid signaling
Twins
Monozygotic
Disease monitoring
Middle Aged
medicine.disease
Pathophysiology
blood [Multiple Sclerosis]
3. Good health
blood [Phosphatidylcholines]
030104 developmental biology
Endocrinology
Blood biomarkers
Acyl chain
Phosphatidylcholines
lipids (amino acids
peptides
and proteins)
Female
Neurology (clinical)
blood [Diseases in Twins]
business
Brief Communications
030217 neurology & neurosurgery
Biomarkers
Zdroj: Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology 7(12), 2461-2466 (2020). doi:10.1002/acn3.51216
ISSN: 2328-9503
DOI: 10.1002/acn3.51216
Popis: Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS. We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co‐twins with MS compared to their non‐affected siblings. Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.
Databáze: OpenAIRE
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