A Decennium of Etiology and Antimicrobial Susceptibility Patterns in Patients with Infective Endocarditis at a University Hospital, Thailand
| Autor: | Chankit Puttilerpong, Chotirat Nakaranurack, Gompol Suwanpimolkul |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Cefotaxime 030106 microbiology Streptococcus suis Microbial Sensitivity Tests medicine.disease_cause Group B Microbiology Hospitals University 03 medical and health sciences 0302 clinical medicine medicine Animals Humans 030212 general & internal medicine Aged Retrospective Studies Inpatients biology Bacteria business.industry Streptococcus Fungi General Medicine Endocarditis Bacterial Middle Aged Antimicrobial medicine.disease biology.organism_classification Thailand Surgery Anti-Bacterial Agents Penicillin Infectious Diseases Infective endocarditis Vancomycin Female business medicine.drug |
| Zdroj: | Japanese journal of infectious diseases. 70(3) |
| ISSN: | 1884-2836 |
| Popis: | Infective endocarditis is an infection with a high mortality rate. Antimicrobial therapy is important for treatment, but data on antimicrobial susceptibilities are limited. This retrospective study analyzed data on the causative microorganisms and antimicrobial susceptibility patterns in patients with infective endocarditis 18 years of age or older who received inpatient care between 2006 and 2015 at King Chulalongkorn Memorial Hospital. A total of 213 patients fulfilled the inclusion criteria. Streptococcus spp. (54.5%) was the most common organism. Viridans streptococcus (46%) was the leading pathogen, followed by Group B streptococcus (27%). The majority of Streptococcus spp. were susceptible to penicillin (82.7%). Among Streptococcus spp., Streptococcus suis had the highest MIC90 of penicillin and cefotaxime (1.65 and 0.95 μg/ml, respectively). There was a statistically significant increase in the MICs of penicillin and cefotaxime for Streptococcus suis (P = 0.03 and 0.04). Only 45.5% of Streptococcus suis and 77.5% of Viridans streptococcus were susceptible to penicillin. All Enterococcus spp. and Staphylococcus spp. were susceptible to vancomycin. In conclusion, the prevalence of Group B streptococcus isolates increased among patients with infective endocarditis in Thailand. Streptococcus suis had the highest MIC90 and proportion of isolates not susceptible to penicillin. Rigorous restriction of the use of antimicrobial agents in animal feeds should be a primary concern. |
| Databáze: | OpenAIRE |
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