Trends and correlation between antibacterial consumption and carbapenem resistance in gram-negative bacteria in a tertiary hospital in China from 2012 to 2019

Autor: Guangyi Meng, Lijuan Zhou, Pingzhi Peng, Chunhong Liang, Liqiu Zhong, Xueyan Zhang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Acinetobacter baumannii
medicine.medical_specialty
China
Gram-negative bacteria
medicine.drug_class
030106 microbiology
Cephalosporin
Antibiotics
Drug resistance
Infectious and parasitic diseases
RC109-216
Microbial Sensitivity Tests
Burkholderia cepacia
Tertiary Care Centers
03 medical and health sciences
0302 clinical medicine
Microbial
Internal medicine
Drug Resistance
Bacterial
medicine
polycyclic compounds
Humans
030212 general & internal medicine
Retrospective Studies
biology
business.industry
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
Antimicrobial
bacterial infections and mycoses
Anti-Bacterial Agents
Cephalosporins
Penicillin
Infectious Diseases
Carbapenems
Tetracyclines
Antibacterial consumption
Linear Models
bacteria
business
Gram-Negative Bacterial Infections
beta-Lactamase Inhibitors
Enterobacter cloacae
medicine.drug
Research Article
Zdroj: BMC Infectious Diseases
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021)
ISSN: 1471-2334
Popis: Background To investigate the trends and correlation between antibacterial consumption and carbapenem resistance in Gram-negative bacteria from 2012 to 2019 in a tertiary-care teaching hospital in southern China. Methods This retrospective study included data from hospital-wide inpatients collected between January 2012 and December 2019. Data on antibacterial consumption were expressed as defined daily doses (DDDs)/1000 patient-days. Antibacterials were classified according to the Anatomical Therapeutic Chemical (ATC) classification system. The trends in antimicrobial usage and resistance were analyzed by linear regression, while Pearson correlation analysis was used for assessing correlations. Results An increasing trend in the annual consumption of tetracyclines, β-lactam/β-lactamase inhibitor (BL/BLI) combinations, and carbapenems was observed (P Acinetobacter baumannii (A. baumannii) significantly increased (P A. baumannii (P Escherichia coli (E. coli; P A. baumannii to carbapenems was positively correlated with cephalosporin/β-lactamase inhibitor (C/BLI) combinations (P P Burkholderia cepacia (B. cepacia) to carbapenems (P P P Enterobacter cloacae (E. cloacae) to carbapenems. Conclusion These results revealed significant correlations between consumption of antibiotics and carbapenem resistance rates in Gram-negative bacteria. Implementing proper management strategies and reducing the unreasonable use of antibacterial drugs may be an effective measure to reduce the spread of carbapenem-resistant Gram-negative bacteria (CRGN), which should be confirmed by further studies.
Databáze: OpenAIRE
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