Cerebrospinal Fluid Apolipoprotein E, Calcium and Cerebral Vasospasm after Subarachnoid Hemorrhage
| Autor: | Yvette P. Conley, Yookyung Kim, Leslie A. Hoffman, Amin B. Kassam, Sheila Alexander, Jeffrey R. Balzer, Michael Horowitz, Mary E. Kerr |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Apolipoprotein E Pathology medicine.medical_specialty Subarachnoid hemorrhage chemistry.chemical_element Calcium Calcium in biology Apolipoproteins E Cerebrospinal fluid Cerebral vasospasm Humans Vasospasm Intracranial Medicine cardiovascular diseases Research and Theory business.industry Middle Aged Subarachnoid Hemorrhage medicine.disease nervous system diseases chemistry Anesthesia cardiovascular system Female lipids (amino acids peptides and proteins) business |
| Zdroj: | Biological Research For Nursing. 10:102-112 |
| ISSN: | 1552-4175 1099-8004 |
| Popis: | Intracellular calcium (Ca++) regulation of cerebral vessels is impaired after subarachnoid hemorrhage (SAH), making secondary pathways, such as that involving apolipoprotein E, potentially more influential. To evaluate cerebrospinal fluid (CSF) apolipoprotein E and Ca++levels as biomarkers of cerebral vasospasm, we examined changes in levels over time and apolipoprotein E (APOE) ε4 allele presence after SAH in individuals with and without vasospasm. We hypothesized that individuals with low apolipoprotein E levels, increased Ca++levels and/or at least one copy of the APOE ε4 allele would have vasospasm. Daily samples from 50 participants, aged 18—75, with SAH were used to quantify apolipoprotein E and Ca++levels. Vasospasm was verified using cerebral angiogram and/or elevated transcranial Dopplers in combination with clinical neurologic deterioration. Overall apolipoprotein E levels were higher in individuals with the APOE ε4 allele (p = .02) or angiographic vasospasm (p = .01), but there were no differences between individuals with and without symptomatic vasospasm. There were no significant changes in apolipoprotein E levels over time. Individuals with the ε4 allele had lower Ca++levels (p = .02) with trends suggesting a different pattern of change over time (p = .07). CSF Ca++levels were lower in individuals with symptomatic vasospasm (p < .01). Change in apolipoprotein E and Ca++levels (p = .006) correlated over time regardless of genotype or vasospasm status. These findings suggest that apolipoprotein E and Ca++may be interacting after SAH, but this interaction does not appear to influence vasospasm. |
| Databáze: | OpenAIRE |
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