Retrospective assessment of potential interaction between levofloxacin and warfarin
| Autor: | Gabriel Antonio Mercadal Orfila, Elisabet Leiva Badosa, Maria Perayre Badía, Concepción Reynaldo Martínez, Ramón José Jódar Masanés, Berta Gracia García |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Ofloxacin medicine.medical_specialty Time Factors Pharmaceutical Science Pharmacy Levofloxacin Toxicology Internal medicine medicine Humans Drug Interactions heterocyclic compounds Pharmacology (medical) Clinical significance International Normalized Ratio cardiovascular diseases Intensive care medicine Aged Retrospective Studies Aged 80 and over Pharmacology Inpatients business.industry Warfarin Anticoagulants Retrospective cohort study General Medicine Middle Aged Drug interaction Anti-Bacterial Agents Concomitant Female business Alcohol consumption Biomarkers medicine.drug |
| Zdroj: | Pharmacy World & Science. 31:224-229 |
| ISSN: | 1573-739X 0928-1231 |
| Popis: | Objective There is currently a controversy regarding interactions between levofloxacin and warfarin. The aim of this study was to determine the clinical relevance of this interaction in our setting. Setting A university hospital in Barcelona, Spain. Methods We carried out a retrospective evaluation of all patients hospitalized in our hospital during the period 2000–2005, selecting all those concomitantly treated with levofloxacin and warfarin for the study. The following data were compiled: demographic information, concomitant medication, comorbid conditions, and relevant analytical parameters, particularly the international normalized ratio (INR), including values taken before, during, and after concomitant administration of the two study drugs. Patients for whom INR values during concomitant administration were not available were excluded. Differences in INR before and during the potential interaction, and before and after the interaction were analyzed with the Wilcoxon t test using SPSS (V12.0). In addition, patients were stratified according to presence or not of toxic habits (smoking/alcohol consumption) to investigate the possible impact of these factors on the interaction under study. Results Among the 30 patients identified, 9 were excluded because INR data during concomitant administration of warfarin and levofloxacin were not available. Statistical analysis demonstrated significant increase in INR (P = 0.001) following addition of levofloxacin to warfarin therapy. Conclusions. The results of this study reaffirm the hypothesis that concomitant administration of levofloxacin and warfarin leads to INR increase; hence close monitoring of INR is advisable when patients are prescribed this combination of drugs. |
| Databáze: | OpenAIRE |
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