Functional changes of brainstem reflexes in Parkinson's disease conditioning of the blink reflex R2 component by paired and index finger stimulation
| Autor: | A. Moglia, J. L. Pepin, A. Lozza, G. G. Rapisarda, P. J. Delwaide |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Parkinson's disease Conditioning Classical Stimulation Fingers Interneurons medicine Humans Corneal reflex Biological Psychiatry Analysis of Variance Electroshock Blinking Classical conditioning Parkinson Disease Index finger Middle Aged Supraorbital nerve medicine.disease Psychiatry and Mental health medicine.anatomical_structure Neurology Reflex Conditioning Operant Female Neurology (clinical) Hypoactivity Psychology Orbit Neuroscience Brain Stem |
| Zdroj: | Journal of Neural Transmission. 104:679-687 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | Recovery curves of the R2 component of the blink reflex have been studied in 10 control subjects and 13 parkinsonian patients both after ipsilateral paired stimulation of the supraorbital nerve and after index finger stimulation. In control subjects, both types of conditioning induced a comparable marked inhibition lasting more than 600 ms. In parkinsonian patients, inhibition was reduced after both conditionings. However, differences appeared in the magnitude of the changes: after paired stimulation, it was less significant (ANOVA and post-hoc Duncan's test: p = 0.04) than after index finger stimulation (p = 0.002). In that latter situation, the more marked reduction in inhibition is interpreted, in the light of current physiologic knowledge, by hypoactivity of the Nucleus Reticularis Giganto Cellularis (NRGC) which would make less efficient inhibitory interneurones in the trigemino-facial pathway. The results are thus compatible with the suggestion that NRGC is made indirectly less active in Parkinson's disease. |
| Databáze: | OpenAIRE |
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