Nucleic acid immunization: concepts and techniques associated with third generation vaccines
| Autor: | A. M. Abai, D.R. Harper, W.J.W. Morrow, U.A. Hasan, Brendan W. Wren |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Clinical Trials as Topic
Cmv cytomegalovirus Genetic Vectors Immunology Biology Virology Third generation DNA vaccination Animal model Gene selection Hcv hepatitis c virus Adjuvants Immunologic Immunization Vaccines DNA Nucleic acid Animals Humans Immunology and Allergy Promoter Regions Genetic T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of Immunological Methods. 229:1-22 |
| ISSN: | 0022-1759 |
| Popis: | A radical change in vaccine methodology arrived nine years ago with the advent of nucleic acid immunization. Aspects such as plasmid design, gene selection, the use of immunostimulatory complexes and clinical trials are discussed in this review. Furthermore, concepts and protocols involved in the construction, evaluation and immunization of a DNA vaccine have been examined as new strategies to enhance this technology continues to grow. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect