Effects of probiotics and synbiotic supplementation on antioxidant status: A meta-analysis of randomized clinical trials
| Autor: | Meisam Barati, Ehsan Ghaedi, Marziyeh Najafi, Mehraneh Karimzedeh, Omid Nikpayam, Hanieh Roshan, Jamal Rahmani |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant Synbiotics Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Subgroup analysis medicine.disease_cause Gastroenterology Antioxidants law.invention Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Randomized Controlled Trials as Topic Inflammation 030109 nutrition & dietetics Nutrition and Dietetics biology business.industry Probiotics Glutathione Oxidative Stress Treatment Outcome chemistry Meta-analysis Dietary Supplements biology.protein business Oxidative stress |
| Zdroj: | Clinical nutrition ESPEN. 30 |
| ISSN: | 2405-4577 |
| Popis: | Summary Background and aim Oxidative stress implicated in the pathogenesis of several diseases. Anti-oxidative characteristics of probiotics reported previously. Thus, we aimed to critically investigate the effectiveness of probiotics and synbiotics supplementation on antioxidant biomarkers. Methods A comprehensive search of Scopus and Medline was performed up to November 2017. All randomized controlled trials (RCT) which evaluate the effect of probiotics or synbiotics on superoxide dismutase (SOD) activity, total antioxidant capacity (TAC) and glutathione (GSH) levels were included. Weighted mean difference (WMD) were pooled using random effect model. Results Sixteen eligible RCTs with 915 participants were included in present study. Findings showed that probiotics could significantly increase GSH level compared to the control groups ((WMD): 132.36, 95% CI: 27.76, 236.95, P = 0.01). Because of considerable heterogeneity among included the studies, subgroup analyses were conducted. Subgroup analysis revealed that GSH level significantly increased in non-diabetic individuals; the effect size was not significant in diabetic patients. Furthermore, probiotics and synbiotics showed no significant effect on TAC level (WMD: 0.04, 95% CI: −0.07, 0.15, P: 0.50) and SOD activity (WMD: 0.04, 95% CI: −0.06, 0.13, P = 0.43). Conclusion Probiotics and synbiotics supplementation improve GSH as a biomarkers of antioxidant status in the body. However, additional studies needed for concluding about TAC and SOD activity. |
| Databáze: | OpenAIRE |
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