Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
| Autor: | Palanisamy Arulselvan, Benjamin M. Geilich, Thomas J. Webster, Mohamed E. El Zowalaty, Mohd Zobir Hussein, Sharida Fakurazi, Bullo Saifullah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Drug
isoniazid Tuberculosis Materials science Magnesium Hydroxide Cell Survival media_common.quotation_subject Biophysics Antitubercular Agents Pharmaceutical Science Bioengineering Aluminum Hydroxide Pharmacology engineering.material Cell Line Nanocomposites Biomaterials Mycobacterium tuberculosis chemistry.chemical_compound Mice Drug Delivery Systems International Journal of Nanomedicine Mg/Al LDH Drug Discovery medicine Animals Humans nanodelivery system media_common Original Research biology Organic Chemistry Isoniazid Layered double hydroxides General Medicine medicine.disease Biocompatible material biology.organism_classification Drug Combinations chemistry tuberculosis engineering NIH 3T3 Cells Hydroxide Mouse Fibroblast medicine.drug |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 1176-9114 |
| Popis: | Bullo Saifullah,1 Palanisamy Arulselvan,2 Mohamed Ezzat El Zowalaty,2,3 Sharida Fakurazi,2,4 Thomas J Webster,5,6 Benjamin M Geilich,5 Mohd Zobir Hussein1 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Department of Environmental Health, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia; 4Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 5Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB. Keywords: tuberculosis, isoniazid, Mg/Al LDH, nanodelivery system |
| Databáze: | OpenAIRE |
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