The role of OCT- angiography in predicting anatomical and functional recovery after endoscopic endonasal pituitary surgery: A 1-year longitudinal study

Autor: Gilda Cennamo, Fausto Tranfa, Luigi D'Andrea, Domenico Solari, Luigi Maria Cavallo, Maria Rosaria Scala, Daniela Montorio
Přispěvatelé: Cennamo, G., Solari, D., Montorio, D., Scala, M. R., Dandrea, L., Tranfa, F., Cavallo, L. M.
Rok vydání: 2021
Předmět:
Male
Longitudinal study
Visual acuity
genetic structures
Cardiovascular Procedures
Vision
Nerve fiber layer
Visual Acuity
Optic chiasm
Social Sciences
Longitudinal Studie
Vascular Surgery
Diagnostic Radiology
chemistry.chemical_compound
Nerve Fibers
Medicine and Health Sciences
Psychology
Pituitary Neoplasm
Longitudinal Studies
Prospective Studies
Fluorescein Angiography
Prospective cohort study
Tomography
Visual Impairments
Multidisciplinary
Radiology and Imaging
Middle Aged
Ganglion
medicine.anatomical_structure
Treatment Outcome
Nerve Fiber
Medicine
Female
Sensory Perception
medicine.symptom
Anatomy
Tomography
Optical Coherence
Human
Research Article
Adenoma
Adult
Natural Orifice Endoscopic Surgery
medicine.medical_specialty
Imaging Techniques
Science
Surgical and Invasive Medical Procedures
Research and Analysis Methods
Retina
Pituitary adenoma
Diagnostic Medicine
Ophthalmology
Endoscopic Surgery
Preoperative Care
medicine
Humans
Pituitary Neoplasms
business.industry
Cognitive Psychology
Biology and Life Sciences
Retinal
Endoscopy
medicine.disease
eye diseases
Capillaries
Prospective Studie
chemistry
Cardiovascular Anatomy
Cognitive Science
Blood Vessels
Perception
sense organs
business
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260029 (2021)
ISSN: 1932-6203
Popis: Purpose The purpose of this study was to investigate the changes in structural spectral-domain optical coherence tomography (SD-OCT), OCT Angiography (OCTA) parameters, and visual acuity, 1 year after endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing optic chiasm and compare outcomes with 48 hours postoperative data. Methods Sixteen eyes of eight patients (4 males, 4 females, mean age 52 ± 11 years) were enrolled in this prospective study. The primary outcome was to evaluate the changes over time before and after surgery, analyzing the Best Corrected Visual Acuity (BCVA), Ganglion Cell Complex (GCC), Retinal Nerve Fiber Layer (RNFL) thicknesses, the retinal vessel density (VD) of Superficial Capillary Plexus (SCP), Deep Capillary Plexus (DCP), Radial Peripapillary Capillary (RPC) and the Foveal Avascular Zone (FAZ). The secondary outcome was to identify potential biomarkers that could predict visual acuity changes after 1-year follow-up. Results When comparing SD-OCT and OCTA measurements obtained after 1 year with those observed 48 hours after surgery, GCC and RNFL were significantly improved. After a significant reduction at 48 hours, GCC thickness showed a significant increase at 1 year after surgery (p = 0.007), while a significant restoration of RNFL thickness was found at 1 year (p = 0.005), as well as the VD of SCP, DCP, and RPC values. FAZ area did not change over time. BCVA significantly improved at each time after surgery (p = 0.037, p = 0.013). A statistically significant correlation was found between the preoperative BCVA, VD of SCP, DCP, RPC, and the postoperative BCVA at 1 year (p = 0.017, p = 0.029, p = 0.031, p = 0.023). Conclusion SD-OCT and OCTA provide helpful information to identify the retinal structural and vascular improvements 1 year after surgery. OCTA parameters could serve as potential predictive markers for visual acuity recovery at long-term follow-up.
Databáze: OpenAIRE
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