Nonfunctioning, Small, Incidental Pancreatic Neuroendocrine Tumors: Results of a Nonoperative Approach Cohort
| Autor: | Lluis Secanella Medayo, Núria Peláez Serra, Carlos Villabona Artero, Juli Busquets Barenys, Joan Fabregat Prous, Sandra Ruiz Osuna, Catalina Uribe Galeano, Emilio Ramos Rubio |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Endoscopic ultrasound medicine.medical_specialty 030230 surgery Neuroendocrine tumors Asymptomatic 03 medical and health sciences 0302 clinical medicine medicine Humans Aged Retrospective Studies Aged 80 and over Incidental Findings medicine.diagnostic_test business.industry Octreotide scan General Engineering Magnetic resonance imaging Middle Aged medicine.disease Tumor Burden Surgery Pancreatic Neoplasms Fine-needle aspiration 030220 oncology & carcinogenesis Radiological weapon Cohort Female Radiology medicine.symptom business |
| Zdroj: | Cirugía Española (English Edition). 95:83-88 |
| ISSN: | 2173-5077 |
| Popis: | The availability of new imaging techniques has conditioned an increase in the incidental diagnosis of small nonfunctioning pancreatic neuroendocrine tumors (PNET-NF). The best treatment is controversial, some authors advise a conservative approach in selected cases. Our aim is to analyze the evolution of incidental, small size PNET-NF, treated with clinical follow-up without surgery.We performed a retrospective analysis of a prospective database of patients diagnosed incidentally with PNET-NF since November 2007 to September 2015. We include those with PNET-NF ≤2cm and asymptomatic. The diagnosis was performed using imaging tests indicating endoscopic ultrasound-guided fine-needle aspiration in case of doubts in the diagnosis. The follow-up was performed at our center, registering clinical and/or radiological changes.We included 24 patients with a median age of 70 years, and a similar distribution in terms of sex. The diagnosis was made through computed tomography multidetector or magnetic resonance imaging and octreotide scan. The tumors were located mainly in the head and neck (46%), with a mean size of 11,5±3,55mm at diagnosis (5-19mm). In 2 cases endoscopic ultrasound fine needle aspiration was used (8%), confirming the diagnosis of low-grade PNET with Ki675%. The median follow-up was 39 months (7-100). In 19 patients (79%) they remained the same size, 21% (5) increased its size with a mean of 2,6±2mm (1-6). No cases had progression of disease.In selected patients, non-surgical management of PNET-NF is an option to consider, when they are asymptomatic and ≤2cm. Larger studies with more patients and more time of follow-up are needed to validate this non-operative approach. |
| Databáze: | OpenAIRE |
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