A Pro 12 Ala substitution in the PPARγ2 polymorphism may decrease the number of diseased vessels and the severity of angiographic coronary artery
| Autor: | Najjar Mohamed Fadhel, Slimani Afef, Neffati Fadoua, Slimane Mohamed Naceur, Ben Hamda Khaldoun, Sarraj Mohamed Youssef, Najah Mohamed |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Acute coronary syndrome Proline Coronary Artery Disease Coronary Angiography Severity of Illness Index Coronary artery disease Insulin resistance Gene Frequency Predictive Value of Tests Risk Factors Polymorphism (computer science) Internal medicine Genotype Odds Ratio medicine Humans Insulin Genetic Predisposition to Disease Allele Allele frequency Aged Aged 80 and over Alanine Chi-Square Distribution Polymorphism Genetic business.industry General Medicine Middle Aged medicine.disease Coronary Vessels PPAR gamma Phenotype Endocrinology Amino Acid Substitution Case-Control Studies Cardiology Homeostatic model assessment Female Insulin Resistance Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Coronary Artery Disease. 24:347-351 |
| ISSN: | 0954-6928 |
| DOI: | 10.1097/mca.0b013e328361a95e |
| Popis: | AIMS Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that regulates the gene expression of the key proteins involved in lipid metabolism, vascular inflammation, and proliferation. PPARγ may contribute toward attenuation of atherogenesis. We investigated the relationship of the Pro 12 Ala PPARγ2 polymorphism with the presence and severity of coronary artery disease (CAD) assessed by Gensini score (Gs). MATERIALS AND METHODS A total of 239 patients and 244 control individuals were investigated for clinical, biochemical, anthropometric, and angiographic information. Standard definitions were used to diagnose patients with acute coronary syndrome. The Gs system was used to calculate the severity of CAD. The computer model Homeostatic Model Assessment (HOMA) 2 was used to determine β-cell function (HOMA-β), insulin sensitivity (HOMA-S), and insulin resistance (HOMA-IR). PCR-RFLP was performed for DNA genotyping for Pro 12 Ala in the PPARγ2 polymorphism. RESULTS Allele frequencies were 0.842 for the Pro allele and 0.158 for the Ala allele. The diseased vessel number was lower in patients with the Ala allele than others. The Gs tended to be lower in patients with the Ala allele than in others [10 (8-16) vs. 24 (16-32), P |
| Databáze: | OpenAIRE |
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