Intensity of antigen expression reflects IGHV mutational status and Dohner-defined prognostic categories in chronic lymphocytic leukemia, monoclonal B-cell lymphocytosis, and small lymphocytic lymphoma
| Autor: | Gregory A. Jasper, Neil Basumallik, Adrian Wiestner, Gerald E. Marti, Clare Sun, Constance M. Yuan, Maryalice Stetler-Stevenson, Robert Matulonis, Jayalakshmi P. Balakrishna, Dalia A. Salem, Drake Scott |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Lymphocytosis Chronic lymphocytic leukemia Article Lymphocytic lymphoma Flow cytometry 03 medical and health sciences 0302 clinical medicine Antigen immune system diseases hemic and lymphatic diseases medicine Humans B-Lymphocytes medicine.diagnostic_test business.industry Hematology Prognosis bacterial infections and mycoses medicine.disease Leukemia Lymphocytic Chronic B-Cell Oncology 030220 oncology & carcinogenesis Mutation Monoclonal Cancer research Monoclonal B-cell lymphocytosis medicine.symptom Immunoglobulin Heavy Chains IGHV@ business 030215 immunology |
| Zdroj: | Leuk Lymphoma |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | We demonstrate the prognostic utility of antigen quantitation in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis (MBL). Median antibody-bound-per-cell (ABC) of CD20, CD22, CD25, CD19, and %CD38(+) was determined in CLL (185/208), SLL (8/208) and MBL (15/208) cases by flow cytometry, then compared to Dohner-classification, immunoglobulin status (mutated, IGHV-M; unmutated, IGHV-U), CLL-IPI risk and time to first treatment (TTFT). Trisomy 12 cases showed increased %CD38-expression (p=0.0379). Higher %CD38 was observed in IGHV-U versus IGHV-M (p=0.0003). CD20ABC was increased in IGHV-U versus IGHV-M (p=0.006). Del13q cases demonstrated lower CD22ABC (p=0.0198). Cases without cytogenetic abnormality exhibited higher CD19ABC (p=0.0295) and CD22ABC (p=0.0078). Del17p cases demonstrated lower CD25ABC (p=0.0097). High and very-high CLL-IPI risk groups were associated with high CD38-expression (p=0.02) and low CD25ABC (p=0.0004). Shortened TTFT was associated with high CD38-expression (p |
| Databáze: | OpenAIRE |
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