Mannitol and glucose
| Autor: | Kenneth R. Sirinek, James T. Spaeth, Edward W. Martin, Neil R. Thomford, Ernest L. Mazzaferri, Samuel Cataland, Thomas M. O'Dorisio |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Isotonic saline Duodenum Physiology Endogeny Gastric Inhibitory Polypeptide Sodium Chloride Gastrointestinal Hormones Dogs Gastric inhibitory polypeptide Transplant surgery Glucose Solution Hypertonic Internal medicine medicine Animals Mannitol Secretion Intubation Gastrointestinal Inhibitory effect Gastric Juice Chemistry Gastroenterology General Medicine Glucose Endocrinology Gastric Mucosa Gastric acid Pentagastrin Secretory Rate medicine.drug |
| Zdroj: | The American Journal of Digestive Diseases. 23:1079-1083 |
| ISSN: | 1573-2568 0002-9211 |
| DOI: | 10.1007/bf01072882 |
| Popis: | Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P less than 0.05) between 30 and 120 min and there was a significant inhibition (P less than 0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r = 0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P less than 0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink