Interleukin-10 and -12 Predict Chemotherapy-Associated Toxicity in Esophageal Adenocarcinoma
| Autor: | Bernhard Holzmann, Wolfram T. Knoefel, Joerg Theisen, Matthias Schauer, Helmut Friess, Matthias Peiper |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Oncology
Pulmonary and Respiratory Medicine Adult Male Mucositis medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Leucovorin Enzyme-Linked Immunosorbent Assay Adenocarcinoma Neoadjuvant chemotherapy Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Biomarkers Tumor Humans Prospective Studies Prospective cohort study Survival rate Neoadjuvant therapy Aged Neoplasm Staging Cisplatin Chemotherapy business.industry Interleukin Middle Aged medicine.disease Prognosis Interleukin-12 Neoadjuvant Therapy Interleukin-10 Survival Rate Mucositis-associated sepsis Toxicity Cytokines Female Toxcicity Fluorouracil business medicine.drug |
| Zdroj: | Journal of Thoracic Oncology. (11):1849-1854 |
| ISSN: | 1556-0864 |
| DOI: | 10.1097/JTO.0b013e3181f19028 |
| Popis: | Introduction:Chemotherapy-associated mucositis often prevents completion of an entire chemotherapy cycle. The underlying pathophysiology of chemotherapy-associated mucositis has not been well established. The individual immunologic predisposition of patients seems to play an important role.Methods:One hundred fifty-six patients with locally advanced or metastatic esophageal adenocarcinoma received neoadjuvant chemotherapy with cisplatin, 5-fluorouracil, and leucovorin followed by resection. Before the neoadjuvant therapy, monocytes were isolated from blood samples and were stimulated with lipopolysaccharide and interferon. An enzyme-linked immunosorbent assay was used to measure interleukin (IL)-10 and -12 levels and correlated with patients' clinical course.Results:Twenty-two patients (14,1%) developed grade III to IV mucositis (according to the NCI-Common toxicity criteria scales) within the neoadjuvant chemotherapy. Pretherapeutic low IL-10 (5500 pg/ml) levels were significantly associated with mucositis causing a therapy interruption or even cessation. Patients with high IL-10 (>43.6 pg/ml) and low IL-12 ( |
| Databáze: | OpenAIRE |
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