HLA-DRw6 and renal allograft rejection
| Autor: | F.H.J. Claas, G.F.J. Hendriks, B. Cohen, D'Amaro J, J. J. Van Rood, Guido G. Persijn, Geziena M.Th. Schreuder |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Graft Rejection
medicine.medical_specialty High responder Urology Histocompatibility Testing Human leukocyte antigen medicine Humans Kidney transplantation General Environmental Science Kidney business.industry Graft Survival Histocompatibility Antigens Class II General Engineering HLA-DR Antigens General Medicine medicine.disease Kidney Transplantation Surgery medicine.anatomical_structure Waiting list Renal allograft Kidney Failure Chronic General Earth and Planetary Sciences Graft survival business Research Article |
| Zdroj: | BMJ. 286:85-87 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.286.6359.85 |
| Popis: | HLA-DRw6-positive patients are "high responders" to certain renal allograft antigens. A study was therefore conducted of the outcome of 247 first renal allografts in 74 DRw6-positive and 173 DRw6-negative recipients. The effectiveness of matching for HLA-DR determinants in both groups was also analysed. The one-year graft survival in DRw6-positive patients was 59% as compared with 75% in DRw6-negative recipients (p = 0.012). A striking difference between the two groups was that HLA-DR matching significantly improved renal allograft survival only in the DRw6-positive patients. In those patients the one-year survival of HLA-DR-identical grafts was 95% as compared with only 38% for 2-DR mismatched grafts (p = 0.009). In DRw6-negative patients only a slight beneficial effect of HLA-DR matching was observed (83% versus 72% at one year for the 0-DR and 2-DR mismatched grafts, respectively) (p greater than 0.05). These findings are clear evidence that DRw6-positive patients (about a quarter of the patients on the waiting list of Eurotransplant) should be given HLA-DR-identical kidney transplants only. |
| Databáze: | OpenAIRE |
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