Response to stress inDrosophilais mediated by gender, age and stress paradigm
| Autor: | Andres R Nieto-Romero, Wendi S. Neckameyer |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Physiology Context (language use) Biology Article Developmental psychology Behavioral Neuroscience Sex Factors Neuroplasticity Animals Homeostasis Swimming Behavior Animal Ethanol Endocrine and Autonomic Systems Sexual Development Stressor Age Factors Brain Central Nervous System Depressants Adaptive response biology.organism_classification Sexual dimorphism Psychiatry and Mental health Drosophila melanogaster Neuropsychology and Physiological Psychology Female Neuroscience Locomotion Stress Psychological Behavioural despair test |
| Zdroj: | Stress. 18:254-266 |
| ISSN: | 1607-8888 1025-3890 |
| DOI: | 10.3109/10253890.2015.1017465 |
| Popis: | All living organisms must maintain equilibrium in response to internal and external challenges within their environment. Changes in neural plasticity (alterations in neuronal populations, dendritic remodeling, and synaptic turnover) are critical components of the homeostatic response to stress, which has been strongly implicated in the onset of affective disorders. However, stress is differentially perceived depending on the type of stress and its context, as well as genetic background, age and sex; therefore, an individual’s maintenance of neuronal homeostasis must differ depending upon these variables. We established Drosophila as a model to analyze homeostatic responses to stress. Sexually immature and mature females and males from an isogenic wild-type strain raised under controlled environmental conditions were exposed to four reproducible and high-throughput translatable stressors to facilitate the analysis of a large number of animals for direct comparisons. These animals were assessed in an open-field arena, in a Light-Dark Box, and in a Forced Swim Test, as well as for sensitivity to the sedative effects of ethanol. These studies establish that immature and mature females and males represent behaviorally distinct populations under control conditions as well as after exposure to different stressors. Therefore, the neural substrates mediating the stress response must be differentially expressed depending upon the hormonal status of the brain. In addition, an adaptive response to a given stressor in one paradigm was not predictive for outcomes in other paradigms. |
| Databáze: | OpenAIRE |
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