Rhabdomyolysis after correction of hyponatremia due to psychogenic polydipsia possibly complicated by clozapine
| Autor: | Olivier Thierry Rutschmann, Gianluca Vecchietti, Jacques Wicki, Haran Burri, Jules Alexandre Desmeules |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Drinking Behavior Sodium Chloride Sodium Chloride/therapeutic use Rhabdomyolysis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Psychogenic disease Humans Pharmacology (medical) Water intoxication Hyponatremia/complications/physiopathology/therapy 030212 general & internal medicine Clozapine ddc:613 ddc:616 Schizophrenia Paranoid biology ddc:617 Rhabdomyolysis/chemically induced/etiology business.industry Schizophrenia Paranoid/complications/drug therapy/physiopathology Metabolic disorder Clozapine/adverse effects/therapeutic use nutritional and metabolic diseases medicine.disease 030227 psychiatry Antipsychotic Agents/adverse effects/therapeutic use Endocrinology Anesthesia biology.protein Creatine kinase Schizophrenic Psychology medicine.symptom business Hyponatremia Polydipsia medicine.drug Antipsychotic Agents |
| Zdroj: | Annals of Pharmacotherapy, Vol. 32, No 9 (1998) pp. 892-895 |
| ISSN: | 1060-0280 |
| Popis: | OBJECTIVE: To report a case of rhabdomyolysis related to rapid correction of hyponatremia attributable to compulsive drinking of water, possibly complicated by clozapine use. CASE SUMMARY: A 42-year-old white man treated with clozapine for schizophrenia was admitted for a generalized seizure. Marked hyponatremia due to psychogenic polydipsia was present. He developed a marked elevation of creatine kinase concentrations after correction of hyponatremia with hyperosmolar sodium solution, without clinical signs of rhabdomyolysis. DISCUSSION: Rhabdomyolysis associated with hyponatremia due to water intoxication has been reported in 17 patients to date. A possible explanation may lie within the framework of the calcium– sodium exchange across the skeletal muscle cell membrane. By increasing muscle cell permeability, clozapine treatment may possibly enhance the destruction of muscle cells. CONCLUSIONS: Hyponatremia due to water intoxication and concurrent use of clozapine should be considered in the differential diagnosis of rhabdomyolysis, especially in the severely psychiatrically disabled population. |
| Databáze: | OpenAIRE |
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