Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus
Autor: | Yusuf B. Byaruhanga, Anika E. Wagner, John H. Muyonga, Aisha Musaazi Sebunya Nakitto |
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Rok vydání: | 2021 |
Předmět: |
Solanum anguivi fruits
Pharmaceutical Science 030209 endocrinology & metabolism Review Type 2 diabetes Pharmacology pathogenesis of diabetes Analytical Chemistry lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine Insulin resistance lcsh:Organic chemistry Drug Discovery glucose homeostasis oxidative stress Medicine Glucose homeostasis Physical and Theoretical Chemistry 030304 developmental biology 0303 health sciences biology antidiabetic business.industry Organic Chemistry Type 2 Diabetes Mellitus Lipid metabolism biology.organism_classification medicine.disease Ascorbic acid Solanum anguivi Insulin receptor antioxidants bioactivity Chemistry (miscellaneous) biology.protein Molecular Medicine type 2 diabetes business |
Zdroj: | Molecules, Vol 26, Iss 2044, p 2044 (2021) Molecules |
ISSN: | 1420-3049 |
Popis: | Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder of glucose homeostasis associated with a status of insulin resistance, impaired insulin signaling, β-cell dysfunction, impaired glucose and lipid metabolism, sub-clinical inflammation, and increased oxidative stress. Consuming fruits and vegetables rich in phytochemicals with potential antidiabetic effects may prevent T2DM and/or support a conservative T2DM treatment while being safer and more affordable for people from low-income countries. Solanum anguivi Lam. fruits (SALF) have been suggested to exhibit antidiabetic properties, potentially due to the presence of various phytochemicals, including saponins, phenolics, alkaloids, ascorbic acid, and flavonoids. For the saponin fraction, antidiabetic effects have already been reported. However, it remains unclear whether this is also true for the other phytochemicals present in SALF. This review article covers information on glucose homeostasis, T2DM pathogenesis, and also the potential antidiabetic effects of phytochemicals present in SALF, including their potential mechanisms of action. |
Databáze: | OpenAIRE |
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