Extensive hard palate hyperpigmentation associated with chloroquine use
| Autor: | Cristiane Loreda Garcia, Elâine Patrícia Alves de Araújo Gomes, Ana Luiza Lima Medeiros Paz, Géssica Vasconcelos Godinho, Luiz Evaristo Ricci Volpato |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Anamnesis medicine.medical_specialty business.industry medicine.disease 030226 pharmacology & pharmacy Chloroquine Phosphate Dermatology Hyperpigmentation 03 medical and health sciences Therapeutic approach 0302 clinical medicine medicine.anatomical_structure Chloroquine Rheumatoid arthritis medicine Pharmacology (medical) 030212 general & internal medicine Hard palate medicine.symptom Adverse effect business Letter to the Editor medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology |
| ISSN: | 1365-2125 0306-5251 |
| Popis: | A 66‐year‐old woman diagnosed clinical manifestation of extensive hard palate hyperpigmentation is presented. Due to historic of rheumatoid arthritis and use of chloroquine phosphate for 3 years, exogenous hyperpigmentation associated with the drug was included among the possible diagnoses. Incisional biopsy was performed and the histopathological exam confirmed exogenous hyperpigmentation compatible with chloroquine use. The patient was referred to the rheumatologist and the ophthalmologist for evaluation of the continuity of the chloroquine use. After one year of follow‐up, no changes were seen in the hyperpigmentation nor other clinical changes. Hyperpigmentation of the hard palate by the use of chloroquine is one of the adverse effects of the chronic use of this drug and does not require specific treatment. The adequate anamnesis and the knowledge about the adverse effects of the drug allowed an adequate therapeutic approach in the case. |
| Databáze: | OpenAIRE |
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