Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study
| Autor: | Linhchi Pham, Van Lam Nguyen, Viet Hung Pham, Vu Phuong Linh Dang, Huu Bich Tran, Thi Thanh Hai Dinh, Thi Kim Anh Le, Son Ngoc Hoang, Duc Minh Nguyen, Minh Diem Dang, Thi Quynh Phan, Daryl, Thanh Hai Le |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Health (social science) Anti-HIV Agents Opportunistic infection HIV Infections Treatment failure 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans Hepatitis B Vaccines Treatment Failure 030212 general & internal medicine Child Retrospective Studies AIDS-Related Opportunistic Infections Platelet Count Proportional hazards model business.industry Public health Age Factors Public Health Environmental and Occupational Health Infant Hepatitis B medicine.disease Antiretroviral therapy CD4 Lymphocyte Count Vaccination Vietnam Case-Control Studies Child Preschool Nested case-control study HIV-1 Female business |
| Zdroj: | International Journal of Public Health. 62:113-119 |
| ISSN: | 1661-8564 1661-8556 |
| Popis: | Over the past decades, Vietnam has made great strides in reducing the rate of mortality in HIV-related deaths, due to increased access of antiretroviral therapy (ART); however, given the significantly high level of treatment failure (TF), it is essential to identify markers that describe the failure of ART in HIV-1 infected children. A nested case–control study was conducted with clinical data collected from 101 HIV-infected children [26 TF and 75 treatment success (TS)] at National Hospital of Pediatrics, Vietnam (2008–2012). The results showed that certain factors including height, weight, vaccination with Hepatitis B, and platelet were significantly different between TF and TS before starting the treatment. In addition, age to start the treatment, CD4 percentage, and opportunistic infection were found to significantly predict treatment outcome most frequently, implying the importance of clinical markers in the treatment response by Cox regression analysis. There is an inherent complexity within clinical markers that is challenging to determine HIV-pediatric failure and further research is needed to build a complete picture to guide clinical, evidence-based practice. |
| Databáze: | OpenAIRE |
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