Increased levels of apoptosis in gastrocnemius skeletal muscle in patients with peripheral arterial disease
| Autor: | Daniel Bensimhon, Robert G. Mitchell, Brian D. Duscha, Jennifer L. Robbins, Brian H. Annex, William E. Kraus, Judith G. Regensteiner, William R. Hiatt, Shelley I. Redfern, Jayer Chung |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Physical exercise Apoptosis Walking 030204 cardiovascular system & hematology 03 medical and health sciences Gastrocnemius muscle 0302 clinical medicine Oxygen Consumption Internal medicine Biopsy medicine Humans Muscle Skeletal Aged Peripheral Vascular Diseases medicine.diagnostic_test business.industry Vascular disease Caspase 3 Skeletal muscle Intermittent Claudication Middle Aged medicine.disease Intermittent claudication United States Surgery Enzyme Activation medicine.anatomical_structure Endocrinology Heart failure Case-Control Studies Exercise Test Female medicine.symptom Cardiology and Cardiovascular Medicine business Claudication 030217 neurology & neurosurgery |
| Zdroj: | Vascular medicine (London, England). 12(4) |
| ISSN: | 1358-863X |
| Popis: | Intermittent claudication (IC) is the major clinical manifestation of peripheral arterial disease (PAD). Apoptosis has been linked to skeletal muscle pathophysiology in other chronic diseases such as congestive heart failure. This study tested the hypothesis that there would be increased levels of apoptosis in the skeletal muscle of patients with PAD compared with control individuals. In total, 26 individuals with PAD and 28 age-appropriate controls underwent studies of peak oxygen consumption (peak VO2) and a gastrocnemius muscle biopsy in the most symptomatic leg. Muscle biopsies were analyzed for apoptosis and caspase-3 activity. Patients with PAD had a reduced peak VO2 compared with controls. Apoptosis was increased in those with PAD compared with age-appropriate controls (3.83% ± 2.6 vs 1.53% ± 0.96; p < 0.001). In conclusion, PAD is associated with increased levels of apoptosis in the peripheral skeletal muscle. Further study is required to ascertain whether apoptosis plays a role in decreased functional capacity. |
| Databáze: | OpenAIRE |
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