Inherited factors contribute to an inverse association between preeclampsia and breast cancer
| Autor: | Per Hall, Haomin Yang, Kamila Czene, Wei He, Mikael Eriksson, Flaminia Chiesa, Jingmei Li, Natalie Holowko |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Breast Neoplasms Lower risk Logistic regression lcsh:RC254-282 Preeclampsia Cohort Studies 03 medical and health sciences symbols.namesake 0302 clinical medicine Breast cancer Pre-Eclampsia Pregnancy Risk Factors Medicine Mammography Humans Poisson regression Breast Mammographic density reproductive and urinary physiology Breast Density Sweden medicine.diagnostic_test business.industry Obstetrics Odds ratio Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens female genital diseases and pregnancy complications 030104 developmental biology 030220 oncology & carcinogenesis Cohort embryonic structures symbols Female business Research Article |
| Zdroj: | Breast Cancer Research, Vol 20, Iss 1, Pp 1-9 (2018) Breast Cancer Research : BCR |
| DOI: | 10.1186/s13058-017-0930-6 |
| Popis: | Background Preeclampsia is frequently linked to reduced breast cancer risk. However, little is known regarding the underlying genetic association and the association between preeclampsia and mammographic density. Methods This study estimates the incidence rate ratios (IRRs) of breast cancer in patients with preeclampsia, when compared to women without preeclampsia, using Poisson regression models in two cohorts of pregnant women: a Swedish nationwide cohort (n = 1,337,934, 1973–2011) and the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA, n = 55,044, 1958–2015). To identify the genetic association between preeclampsia and breast cancer, we used logistic regression models to calculate the odds ratios (ORs) of preeclampsia in sisters of breast cancer patients, and in women with different percentiles of breast cancer polygenic risk scores (PRS). Linear regression models were used to estimate the mammographic density by preeclampsia status in the KARMA cohort. Results A decreased risk of breast cancer was observed among patients with preeclampsia in both the nationwide (IRR = 0.90, 95% CI = 0.85; 0.96) and KARMA cohorts (IRR = 0.75, 95% CI = 0.61; 0.93). Women with high breast cancer PRS and sisters of breast cancer patients had a lower risk of preeclampsia (OR = 0.89, 95% CI = 0.83; 0.96). Mammographic density was lower in women with preeclampsia compared to women without preeclampsia (-2.04%, 95% CI = -2.65; -1.43). Additionally, among sisters in the KARMA cohort (N = 3500), density was lower in sisters of patients with preeclampsia compared to sisters of women without preeclampsia (-2.76%, 95% CI = -4.96; -0.56). Conclusion Preeclampsia is associated with reduced risk of breast cancer and mammographic density. Inherited factors contribute to this inverse association. Electronic supplementary material The online version of this article (doi:10.1186/s13058-017-0930-6) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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