Bioactivity and Mechanical Stability of 45S5 Bioactive Glass Scaffolds Based on Natural Marine Sponges
| Autor: | Lina Altomare, L. De Nardo, Giorgia Novajra, Chiara Vitale-Brovarone, Aldo R. Boccaccini, Tobias Fey, Elena Boccardi, Anahí Philippart, Virginia Melli |
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| Rok vydání: | 2016 |
| Předmět: |
Scaffold
Materials science Biocompatibility Simulated body fluid 0206 medical engineering Biomedical Engineering 02 engineering and technology Cell Line law.invention Mice chemistry.chemical_compound law Materials Testing Animals Porosity Polyurethane Osteoblasts Tissue Scaffolds biology Bioactive glass scaffolds Natural marine sponges 021001 nanoscience & nanotechnology biology.organism_classification 020601 biomedical engineering Porifera Sponge Compressive strength chemistry Chemical engineering Bioactive glass Glass Stress Mechanical 0210 nano-technology |
| Zdroj: | Annals of Biomedical Engineering. 44:1881-1893 |
| ISSN: | 1573-9686 0090-6964 |
| Popis: | Bioactive glass (BG) based scaffolds (45S5 BG composition) were developed by the replica technique using natural marine sponges as sacrificial templates. The resulting scaffolds were characterized by superior mechanical properties (compression strength up to 4 MPa) compared to conventional BG scaffolds prepared using polyurethane (PU) packaging foam as a template. This result was ascribed to a reduction of the total scaffold porosity without affecting the pore interconnectivity (>99%). It was demonstrated that the reduction of total porosity did not affect the bioactivity of the BG-based scaffolds, tested by immersion of scaffolds in simulated body fluid (SBF). After 1 day of immersion in SBF, a homogeneous CaP deposit on the surface of the scaffolds was formed, which evolved over time into carbonate hydroxyapatite (HCA). Moreover, the enhanced mechanical properties of these scaffolds were constant over time in SBF; after an initial reduction of the maximum compressive strength upon 7 days of immersion in SBF (to 1.2 ± 0.2 MPa), the strength values remained almost constant and higher than those of BG-based scaffolds prepared using PU foam ( |
| Databáze: | OpenAIRE |
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