In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue
| Autor: | C. Wayne McIlwraith, John D. Kisiday, David D. Frisbie, Dora J. Ferris |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
lcsh:Internal medicine
Pathology medicine.medical_specialty Article Subject biology business.industry Mesenchymal stem cell Histology Cell Biology Fibrin Repair tissue medicine.anatomical_structure In vivo medicine biology.protein Delivery system Bone marrow lcsh:RC31-1245 Fibrin glue business Molecular Biology Research Article |
| Zdroj: | Stem Cells International Stem Cells International, Vol 2012 (2012) |
| ISSN: | 1687-9678 1687-966X |
| Popis: | Fibrin glue created from a patient's own blood can be used as a carrier to deliver cells to the specific site of an injury. An experimental model for optimizing various permutations of this delivery systemin vivowas tested in this study. Harvested equine meniscal sections were reapposed with fibrin glue or fibrin glue and equine bone marrow-derived mesenchymal stem cells (BMSCs). These constructs were then implanted subcutaneously in nude mice. After harvesting of the constructs, BMSC containing constructs showed significantly increased vascularization, and histology showed subjectively decreased thickness of repair tissue and increased total bonding compared to fibrin alone constructs. This model allowed direct comparison of different meniscal treatment groups while using a small number of animals. Thisin vivomodel could be valuable in the future to optimize fibrin and cellular treatments for meniscal lesions in the horse and potentially humans as well. |
| Databáze: | OpenAIRE |
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