Convenient Route Leading to Neutral fac-M(CO)3(NNO) Complexes (M = Re, 99mTc) Coupled to Amine Pharmacophores

Autor:	Maria Pelecanou, Catherine P. Raptopoulou, Aris Chiotellis, Z. Papadopoulou-Daifoti, Minas Papadopoulos, Aris Terzis, Ioannis Pirmettis, Charalambos Tsoukalas
Rok vydání:	2008
Předmět:	Ions Models Molecular Magnetic Resonance Spectroscopy Molecular Structure Chemistry Stereochemistry Ligand Technetium Crystallography X-Ray Inorganic Chemistry Organometallic Compounds Amine gas treating Amines Physical and Theoretical Chemistry Pharmacophore Chromatography High Pressure Liquid
Zdroj:	Inorganic Chemistry. 47:2601-2607
ISSN:	1520-510X 0020-1669
DOI:	10.1021/ic7019268
Popis:	The synthesis and characterization of three neutral tricarbonyl fac-M(CO)3(NNO) (M = Re, (99m)Tc) complexes based on the picolylamine N,N-diacetic acid (PADA) ligand is reported. One of the two carboxylate groups of the PADA ligand is efficiently and conveniently derivatized with an amine nucleophile through the use of the PADA anhydride. In this work, aniline, benzylamine and pyrrolidine were used as model amine nucleophiles. The rhenium complexes were synthesized using the [NEt4]2[Re(CO)3Br3] precursor and fully characterized by elemental analysis, spectroscopic methods, and X-ray crystallography. The analogous technetium-99m complexes were also prepared quantitatively using the [(99m)Tc(CO)3(H2O)3](+) precursor. The reaction scheme presented for the synthesis of the fac-M(CO)3(NNO) (M = Re, (99m)Tc) complexes can be applied to the development of target-specific radiopharmaceuticals because, in principle, any bioactive pharmacophore bearing an amine group can be used in the place of the model amine nucleophiles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d75881b0ad2c96f4cfe2f8ce633d55 https://doi.org/10.1021/ic7019268 Zobrazit plný text záznamu