An assessment of the cerebroprotective potential of volatile anaesthetics using two independent methods in an in vitro model of cerebral ischaemia
| Autor: | Christopher C. Toner, Karen L. Blatchford, Jonathan A. Stamford, Andrew J Milne, Daniel P. McLaughlin |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Dopamine Pharmacology In Vitro Techniques Sevoflurane Brain Ischemia chemistry.chemical_compound medicine Animals Channel blocker cardiovascular diseases Rats Wistar Neurotransmitter Molecular Biology Chemistry General Neuroscience Enflurane Cell Hypoxia Corpus Striatum Rats Disease Models Animal Neuroprotective Agents Isoflurane Anesthesia Anesthetic Anesthetics Inhalation Catecholamine Neurology (clinical) Halothane Developmental Biology medicine.drug |
| Zdroj: | Brain research. 958(2) |
| ISSN: | 0006-8993 |
| Popis: | Previous studies using a rat brain slice model of cerebral 'ischaemia' (hypoxia and hypoglycaemia) have suggested that volatile anaesthetics may have cerebroprotective potential. In this study, we tested the cerebroprotective profile of four volatile anaesthetics in this model by two independent means: voltammetric measurement of 'ischaemia'-induced dopamine (DA) release and post-'ischaemic' tissue staining with 2,3,5-triphenyltetrazolium chloride (TTC). 'Ischaemia' caused a characteristic pattern of DA release. Halothane, isoflurane and enflurane did not affect the time from onset of 'ischaemia' to the initiation of DA release. However, all three volatile agents significantly increased (P |
| Databáze: | OpenAIRE |
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