Association between age at menopause and fracture risk: a systematic review and meta-analysis
| Autor: | Eustathios Kenanidis, Dimitrios G. Goulis, Konstantinos Christou, Nifon K Gkekas, Pavlos Siolos, Michael Potoupnis, Stavroula A Paschou, John C. Stevenson, Irene Lambrinoudaki, Aikaterini-Maria Artzouchaltzi, Nikoletta Kosmidou, Eleftherios Tsiridis, Panagiotis Anagnostis |
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| Rok vydání: | 2018 |
| Předmět: |
Fracture risk
Aging medicine.medical_specialty Endocrinology Diabetes and Metabolism Age at menopause Menopause Premature Separate analysis 030209 endocrinology & metabolism Premature ovarian insufficiency Fractures Bone 03 medical and health sciences 0302 clinical medicine Endocrinology Bone Density Risk Factors Diabetes mellitus Humans Medicine Osteoporosis Postmenopausal Postmenopausal women Hip Fractures business.industry Obstetrics Age Factors medicine.disease Menopause 030220 oncology & carcinogenesis Meta-analysis Female business Osteoporotic Fractures |
| Zdroj: | Endocrine. 63:213-224 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-018-1746-6 |
| Popis: | Early menopause (EM, age at menopause 45 years) and premature ovarian insufficiency (POI, age at menopause 40 years) are associated with an increased risk of osteoporosis. However, their association with increased fracture risk has not been established, with studies yielding conflicting results. The primary aim of this systematic review and meta-analysis was to synthesize studies evaluating the association between age at menopause and fracture risk. The secondary aim was to evaluate this effect concerning the site of fractures.A comprehensive search was conducted in PubMed, CENTRAL and Scopus, up to 31 January 2018. Data were expressed as odds ratio (OR) with 95% confidence intervals (CI). The IEighteen studies were included in the qualitative and quantitative analysis (462,393 postmenopausal women, 12,130 fractures). Compared with women with age at menopause 45 years, women with EM demonstrated higher fracture risk (OR 1.36, 95% CI 1.11-1.66, p 0.002, I² 81.5%). Women with POI did not display any difference in fracture risk compared either with women with age at menopause 40 (OR 1.23, 95% CI 0.72-2.09, p = 0.436, I² 62.5%) or45 years (OR 0.54, 95% CI 0.22-1.29, p = 0.17, IThis is the first meta-analysis showing that EM is associated with increased fracture risk compared with normal age at menopause, without any distinct effect on the site of the fracture. |
| Databáze: | OpenAIRE |
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