Dalayed Effects of Antitumor Drug Paclitaxel on the Hereditary Material and Hemopoietic System of CBA Mice

Autor:	O. V. Neupokoeva, E. P. Fedorova, L. A. Sandrikina, M. V. Filonova, A. A. Churin, L. A. Stavrova, O. L. Voronova
Rok vydání:	2020
Předmět:	Male 0301 basic medicine Drug Paclitaxel media_common.quotation_subject Antineoplastic Agents Bone Marrow Cells Genomic Instability General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Precursor cell medicine Animals Erythropoiesis media_common Chromosome Aberrations Genome Mutagenicity Tests business.industry General Medicine Hematopoiesis Haematopoiesis 030104 developmental biology medicine.anatomical_structure chemistry Cytogenetic Analysis Mice Inbred CBA Cancer research Bone marrow hypoplasia Cba mice Female Bone marrow business 030217 neurology & neurosurgery
Zdroj:	Bulletin of Experimental Biology and Medicine. 169:43-47
ISSN:	1573-8221 0007-4888
Popis:	Paclitaxel in a single MTD of 40 mg/kg caused chromosome aberrations and genome changes (polyploidy) in the bone marrow cells of mice early and 3 months after the injection. The quantity of early precursors of erythropoiesis in the bone marrow decreased, as did their proliferative potential irrespective of the animal gender. Injection of paclitaxel in the MTD caused the development of bone marrow hypoplasia during the early period of observation (up to 14 days) and 3 months after injection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d222ab51d3c7dc2e13e2ea0458bda0 https://doi.org/10.1007/s10517-020-04820-x Zobrazit plný text záznamu Full text from SpringerLink