Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals
| Autor: | Svitlana Yanchuk, Mykola Dmytrovych Chemych, Kateryna Zhuk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
biomarkers of inflammation
Tuberculosis genetic markers diagnosis ВИЧ-инфекция diagnosis генетические маркеры туберкулëз Bioinformatics Education ко-инфекция Pulmonary tuberculosis Hiv infected диагноз medicine SNP Effective treatment HIV-infection биомаркеры воспаления hiv infection Aids patients business.industry ВІЛ-інфекція ко-інфекція діагноз medicine.disease coinfection генетичні маркери tuberculosis Genetic marker GV557-1198.995 genetic markers Coinfection Medicine біомаркери запалення туберкульоз business Sports |
| Zdroj: | Journal of Education, Health and Sport, Vol 11, Iss 7, Pp 239-249 (2021) |
| ISSN: | 2391-8306 |
| Popis: | Chemych Mykola, Yanchuk Svitlana, Zhuk Kateryna. Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals. Journal of Education, Health and Sport. 2021;11(07): 239-249. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.07.022 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.07.022 https://zenodo.org/record/5189580 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.06.2021. Revised: 12.07.2021. Accepted: 29.07.2021. Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals Mykola Chemych, Svitlana Yanchuk, Kateryna Zhuk Sumy State University 2, Rimsky-Korsakov street, Sumy 40007, Ukraine Mykola Chemych, ORCID ID https://orcid.org/0000-0002-7085-5448 , n.chemych@kinf.sumdu.edu.ua ; Svitlana Yanchuk, ORCID ID https://orcid.org/0000-0003-0130-7947, s.yanchuk@kinf.sumdu.edu.ua Kateryna Zhuk, ORCID ID https://orcid.org/0000-0002-9130-2623 , katerinazhuk11@gmail.com Abstract An important aspect of monitoring, further timely and effective treatment of HIV-TB coinfection is timely and correct diagnosis based on comprehensive clinical, laboratory and instrumental studies. Many factors play a role in the development of tuberculosis in HIV-infected people, but the key and quite important elements are the study of genetic markers and biomarkers of inflammation. A number of studies have been carried out on inflammatory markers, but IL-6, INF-γ, MIG, CRP, IL-18 remain relevant and insufficiently studied in coinfection. A comprehensive study of them will be important in the screening of HIV-TB coinfection). Determining the presence of (SNP) rs4331426 located in chromosome 18q11.2 in HIV-infected and AIDS patients will solve the issue of predisposition to the development of tuberculosis in the early stages of HIV infection and contribute to the development of further tactics of patients treatment and management. Keywords: HIV infection; tuberculosis; coinfection; biomarkers of inflammation; genetic markers, diagnosis. |
| Databáze: | OpenAIRE |
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