Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

Autor: Zhaoyang Li, Zhenduo Cui, Yong Han, Kelvin W.K. Yeung, Yufeng Zheng, Changyi Li, Yuqian Qiao, Xiangmei Liu, Yanqin Liang, Xianbao Wang, Shuilin Wu, Shengli Zhu, Bo Li
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Methicillin-Resistant Staphylococcus aureus
medicine.drug_class
Science
medicine.medical_treatment
Antibiotics
Bacterial killing
General Physics and Astronomy
02 engineering and technology
010402 general chemistry
medicine.disease_cause
01 natural sciences
Microwave assisted
Article
General Biochemistry
Genetics and Molecular Biology
Antimicrobial therapy
Microbiology
Drug Delivery Systems
Drug Therapy
medicine
Animals
Magnetite Nanoparticles
Microwaves
lcsh:Science
Chemotherapy
Multidisciplinary
Nanotubes
Carbon
business.industry
Osteomyelitis
Bioinspired materials
General Chemistry
Staphylococcal Infections
Photothermal therapy
021001 nanoscience & nanotechnology
medicine.disease
Ferrosoferric Oxide
Anti-Bacterial Agents
0104 chemical sciences
Staphylococcus aureus
Gentamicin
lcsh:Q
Rabbits
Bacterial infection
Gentamicins
0210 nano-technology
business
Biomedical engineering
medicine.drug
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
ISSN: 2041-1723
Popis: Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe3O4/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe3O4/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe3O4/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections.
Deep tissue infections can be difficult to treat due to limited light penetration associated with phototherapies. Here, the authors report on a bacterial capture system for antibiotic delivery and microwave-assisted killing of MRSA in osteomyelitis and demonstrate application in vivo.
Databáze: OpenAIRE
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