Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
Autor: | Zhaoyang Li, Zhenduo Cui, Yong Han, Kelvin W.K. Yeung, Yufeng Zheng, Changyi Li, Yuqian Qiao, Xiangmei Liu, Yanqin Liang, Xianbao Wang, Shuilin Wu, Shengli Zhu, Bo Li |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Methicillin-Resistant Staphylococcus aureus
medicine.drug_class Science medicine.medical_treatment Antibiotics Bacterial killing General Physics and Astronomy 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Microwave assisted Article General Biochemistry Genetics and Molecular Biology Antimicrobial therapy Microbiology Drug Delivery Systems Drug Therapy medicine Animals Magnetite Nanoparticles Microwaves lcsh:Science Chemotherapy Multidisciplinary Nanotubes Carbon business.industry Osteomyelitis Bioinspired materials General Chemistry Staphylococcal Infections Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Ferrosoferric Oxide Anti-Bacterial Agents 0104 chemical sciences Staphylococcus aureus Gentamicin lcsh:Q Rabbits Bacterial infection Gentamicins 0210 nano-technology business Biomedical engineering medicine.drug |
Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020) Nature Communications |
ISSN: | 2041-1723 |
Popis: | Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe3O4/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe3O4/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe3O4/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections. Deep tissue infections can be difficult to treat due to limited light penetration associated with phototherapies. Here, the authors report on a bacterial capture system for antibiotic delivery and microwave-assisted killing of MRSA in osteomyelitis and demonstrate application in vivo. |
Databáze: | OpenAIRE |
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