Microwave-assisted synthesis, structural activity relationship and biological activity of some new quinoxaline Schiff base derivatives as highly potent spirochete bactericidal agents
| Autor: | Magharla Dasaratha Dhanaraju, Chandravadivelu Gopi, Vedula Girija Sastry |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Quinoxaline Stereochemistry 030106 microbiology Pharmaceutical Science Medicine (miscellaneous) Leptospira icterohaemorrhagiae 01 natural sciences 03 medical and health sciences chemistry.chemical_compound In vivo Condensation reaction lcsh:Science lcsh:R5-920 Schiff base 010405 organic chemistry Biological activity Oxime Agricultural and Biological Sciences (miscellaneous) In vitro Anti-leptospiral activity 0104 chemical sciences chemistry Proton NMR Schiff bases lcsh:Q lcsh:Medicine (General) |
| Zdroj: | Beni-Suef University Journal of Basic and Applied Sciences, Vol 6, Iss 1, Pp 39-47 (2017) |
| ISSN: | 2314-8535 |
| Popis: | The main aim of this work was to synthesise a new (E)-3-(4-or3-Aminophenylimino) quinoxaline-2(3 H )-one oxime Schiff base derivatives and evaluate the anti-leptospiral activity against Leptospira icterohaemorrhagiae . The mentioned derivatives were prepared by performing microwave-assisted condensation reactions of (E)-3-(4-or3-Aminophenyl imino)quinoxaline-2(3 H )-one and aromatic aldehydes. The structures of these interesting compounds were characterised by FT-IR, 1 H NMR and mass spectroscopy. Furthermore, these compounds were screened for spirocidal activity against Leptospira icterohaemorrhagiae by using in vitro and in vivo method. The anti-leptospiral activity result reveals that most of the compounds were exhibiting considerable activity against Leptospira icterohaemorrhagiae . Compound 6c demonstrated remarkable activity at low concentration against the Leptospira icterohaemorrhagiae as compared to the standard drugs. |
| Databáze: | OpenAIRE |
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