IGF-IR: a new prognostic biomarker for human glioblastoma

Autor:	Christine Decaestecker, Justine Allard, Nicky D'Haene, Sébastien Sauvage, Calliope Maris, Anne-Laure Trepant, M. Le Mercier, Pieter Demetter, Isabelle Salmon, Sandrine Rorive
Rok vydání:	2015
Předmět:	Adult Male Cancer Research Pathology medicine.medical_specialty Techniques d'imagerie et traitement d'images IGF-IR medicine.medical_treatment Kaplan-Meier Estimate Biology Receptor IGF Type 1 Young Adult Biomarkers Tumor medicine Humans Receptor Aged Proportional Hazards Models Aged 80 and over Chemotherapy Tissue microarray Temozolomide Brain Neoplasms Proportional hazards model Growth factor glioblastoma Médecine pathologie humaine Receptors Somatomedin Middle Aged Sciences bio-médicales et agricoles Histopathologie Prognosis Ingénierie biomédicale nervous system diseases Cancérologie Radiation therapy Anatomopathologie Oncology immunohistochemistry Cancer research biomarker Immunohistochemistry Female prognosis Translational Therapeutics medicine.drug
Zdroj:	British Journal of Cancer, 113 (5 British Journal of Cancer
ISSN:	1532-1827 0007-0920
DOI:	10.1038/bjc.2015.242
Popis:	Glioblastomas (GBMs) are the most common malignant primary brain tumours in adults and are refractory to conventional therapy, including surgical resection, radiotherapy and chemotherapy. The insulin-like growth factor (IGF) system is a complex network that includes ligands (IGFI and IGFII), receptors (IGF-IR and IGF-IIR) and high-affinity binding proteins (IGFBP-1 to IGFBP-6). Many studies have reported a role for the IGF system in the regulation of tumour cell biology. However, the role of this system remains unclear in GBMs. SCOPUS: ar.j info:eu-repo/semantics/published
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d050d3a0c557e71bd70d710f6d48bf https://doi.org/10.1038/bjc.2015.242 Zobrazit plný text záznamu Plný text ve formátu PDF