Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents
| Autor: | José de Jesus Ribeiro Gomes de Pinho, Miriam Aparecida de Oliveira Pinto, Orlando Vieira de Sousa, Vanessa dos Santos Temponi, Célia Hitomi Yamamoto, Maria Silvana Alves, Antônia Ribeiro, Glauciemar Del-Vechio-Vieira, Jucélia Barbosa da Silva |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Leukocyte migration Pharmacology Carrageenan lcsh:Chemistry Mice chemistry.chemical_compound Vernonia polyanthes antinociceptive effect anti-inflammatory effect Edema Hot plate lcsh:QH301-705.5 Spectroscopy Pain Measurement Analgesics Anti-Inflammatory Agents Non-Steroidal General Medicine Computer Science Applications Nociception medicine.symptom Paw edema Exudate medicine.drug_class Pain Article Catalysis Anti-inflammatory Inorganic Chemistry medicine Animals Pain Management Rats Wistar Physical and Theoretical Chemistry Molecular Biology Inflammation Ethanol Plant Extracts business.industry Organic Chemistry Rats Plant Leaves lcsh:Biology (General) lcsh:QD1-999 chemistry business Vernonia |
| Zdroj: | International Journal of Molecular Sciences; Volume 13; Issue 3; Pages: 3887-3899 International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 13, Iss 3, Pp 3887-3899 (2012) |
| ISSN: | 1422-0067 |
| Popis: | The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities. |
| Databáze: | OpenAIRE |
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