Manganese Induced neurodegenerative diseases and possible therapeutic approaches
| Autor: | Eun Sook Lee, Alexey A. Tinkov, Michael Aschner, Abel Santamaría, Priscila Gubert, Aaron B. Bowman, Airton Cunha Martins, Marina Meirelles Paes, Gustavo Roberto Villas Boas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Manganese Parkinson's disease business.industry General Neuroscience Public health Heavy metals Neurodegenerative Diseases Disease Bioinformatics medicine.disease Article nervous system diseases 030227 psychiatry 03 medical and health sciences 0302 clinical medicine Huntington's disease medicine Humans Pharmacology (medical) Neurology (clinical) Amyotrophic lateral sclerosis business 030217 neurology & neurosurgery |
| Zdroj: | Expert Rev Neurother |
| Popis: | INTRODUCTION: Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion disease represent important public health concerns. The etiology of neurodegenerative diseases is not completely understood, but genetic factors and environmental factors clearly contribute to their development. As environmental factors, heavy metals such as manganese (Mn) an essential trace element, are required for several physiological processes. In addition, exposures to high levels may culminate in adverse health effects. AREAS COVERED: In this critical review, the authors address the role of Mn in the etiology of neurodegenerative diseases and discuss emerging treatments of Mn overload, such as chelation therapy. In addition, the authors discuss natural and synthetic compounds under development as prospective therapeutics. Moreover, bioinformatic approaches to identify new potential targets and therapeutic substances to reverse the neurodegenerative diseases are discussed. EXPERT OPINION: Here, the authors highlight the importance of better understanding the molecular mechanisms of toxicity associated with neurodegenerative diseases, and the role of Mn in these diseases. Additional emphasis should be directed to the discovery of new agents to treat Mn-induced diseases, since present day chelator therapies have limited bioavailability. Furthermore, the authors encourage the scientific community to develop research using libraries of compounds to screen those compounds that show efficacy in regulating brain Mn levels. In addition, bioinformatics may provide novel insight for pathways and clinical treatments associated with Mn-induced neurodegeneration, leading to a new direction in Mn toxicological research. |
| Databáze: | OpenAIRE |
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