Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation▿
| Autor: | M. J. Soriano, J. Venero, M. de Cueto, Lorena López-Cerero, Jose M. Rodriguez, Álvaro Pascual |
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| Přispěvatelé: | Universidad de Sevilla. Departamento de Microbiología, Ministerio de Sanidad y Consumo. España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
DNA Topoisomerase IV Male Ofloxacin Bacteremia Drug resistance Case Reports Levofloxacin medicine.disease_cause Microbiology Fatal Outcome Streptococcus pneumoniae Drug Resistance Bacterial Medicine Humans heterocyclic compounds Treatment Failure Antibacterial agent Aged biology business.industry biochemical phenomena metabolism and nutrition Pneumonia Pneumococcal Streptococcaceae biology.organism_classification medicine.disease bacterial infections and mycoses Virology Anti-Bacterial Agents Pneumonia DNA Gyrase Mutation (genetic algorithm) Mutation bacteria business medicine.drug |
| Zdroj: | idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| Popis: | The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isolates are discussed. |
| Databáze: | OpenAIRE |
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