Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy
| Autor: | E Leibing, Thomas Meyer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030204 cardiovascular system & hematology Alcoholic cardiomyopathy medicine.disease_cause Pathogenesis Contractility 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Multienzyme Complexes Internal medicine Medicine Animals Humans Alcohol dehydrogenase Ethanol biology business.industry Cardiomyopathy Alcoholic Myocardium Acetaldehyde Models Cardiovascular Heart medicine.disease 030104 developmental biology Endocrinology chemistry Liver Heart failure biology.protein Cardiology and Cardiovascular Medicine business Oxidative stress Signal Transduction |
| Zdroj: | Herz. 41(6) |
| ISSN: | 1615-6692 |
| Popis: | Owing to its acute psychotropic effects, ethanol is the most frequently consumed toxic agent worldwide. However, excessive alcohol intake results in an array of health, social, and economic consequences, which are related to its property as an addictive substance. It has been well established that exposure to high levels of alcohol for a long period leads to the onset and progression of nonischemic cardiomyopathy through direct toxic mechanisms of ethanol and its metabolite, acetaldehyde. Excessive alcohol ingestion causes myocardial damage including disruptions of the myofibrillar architecture and is associated with reduced myocardial contractility and decreased ejection volumes. Key features of alcoholic cardiomyopathy are cardiac hypertrophy and ventricular dilatation, and the disease is manifested mainly as cardiomegaly, congestive heart failure, and even cardiac death. Mechanisms that have been postulated to underlie the pathogenesis of alcoholic cardiomyopathy include apoptosis, mitochondrial alterations, acetaldehyde protein adduct formation, oxidative stress, and imbalances in fatty acid metabolism. In the following, we give a brief overview of the molecular effects of ethanol-metabolizing enzymes and their impact on myocardial signal transduction pathways. |
| Databáze: | OpenAIRE |
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