Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties

Autor: Seok Hyun Yun, Sabine Kling, Susana Marcos, Imran B. Akca, Nandor Bekesi, Giuliano Scarcelli, Ernest W. Chang
Rok vydání: 2014
Předmět:
Frequency response
Intraocular pressure
genetic structures
Vibrography
Swine
01 natural sciences
Biochemistry
vibrography
Cornea
Elasticity Imaging Techniques
0302 clinical medicine
Research Articles
Corneal biomechanical properties
corneal natural frequencies
Biomechanics
3. Good health
non-contact
medicine.anatomical_structure
corneal biomechanical properties
Tomography
Optical Coherence
Biotechnology
Materials science
Biomedical Engineering
Biophysics
Bioengineering
Models
Biological
010309 optics
Biomaterials
03 medical and health sciences
Optics
0103 physical sciences
medicine
Coherence (signal processing)
Animals
Elasticity (economics)
Corneal natural frequencies
business.industry
Non-contact
Natural frequency
Elasticity
eye diseases
030221 ophthalmology & optometry
Cattle
sense organs
business
Biomedical engineering
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of the Royal Society Interface
Journal of The Royal Society Interface
Popis: Most techniques measuring corneal biomechanics in vivo are biased by side factors. We demonstrate the ability of optical coherence tomographic (OCT) vibrography to determine corneal material parameters, while reducing current prevalent restrictions of other techniques (such as intraocular pressure (IOP) and thickness dependency). Modal analysis was performed in a finite-element (FE) model to study the oscillation response in isolated thin corneal flaps/eye globes and to analyse the dependency of the frequency response function on: corneal elasticity, viscoelasticity, geometry (thickness and curvature), IOP and density. The model was verified experimentally in flaps from three bovine corneas and in two enucleated porcine eyes using sound excitation (100¿110 dB) together with a phase-sensitive OCT to measure the frequency response function (range 50¿510 Hz). Simulations showed that corneal vibration in flaps is sensitive to both, geometrical and biomechanical parameters, whereas in whole globes it is primarily sensitive to corneal biomechanical parameters only. Calculations based on the natural frequency shift revealed that flaps of the posterior cornea were 0.8 times less stiff than flaps from the anterior cornea and cross-linked corneas were 1.6 times stiffer than virgin corneas. Sensitivity analysis showed that natural vibration frequencies of whole globes were nearly independent from corneal thickness and IOP within the physiological range. OCT vibrography is a promising non-invasive technique to measure corneal elasticity without biases from corneal thickness and IOP
The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007– 2013)/ERC grant agreement no. 294099 and furthermore from the Spanish Government, MINECO, FIS2011-25637, FPI-BES-2009-024560, Harvard Clinical and Translational Science Center (NIH UL1-RR025758), NIH grant no. P41-EB015903, NSF grant no. CBET-1264356; Comunidad de Madrid and EU (FP7/2007-2013/REA 291820).
Databáze: OpenAIRE
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