The effect of dexamethasone on the expression of activated NF-kappa B in adjuvant arthritis
| Autor: | Isao Takata, Toshiki Takagi, Takashi Murata, Tatsuo Suzuki, Ryuichi Totsuka, Hisako Fujimura, Yasushi Ohmachi, Peter W. Tsao |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Inflammatory arthritis Immunology Anti-Inflammatory Agents Arthritis Inflammation Dexamethasone Pathology and Forensic Medicine chemistry.chemical_compound Edema Internal medicine medicine Immunology and Allergy Animals business.industry NF-kappa B NF-κB medicine.disease Arthritis Experimental Immunohistochemistry Rats Endocrinology chemistry Rats Inbred Lew Corticosteroid Female medicine.symptom business medicine.drug |
| Zdroj: | Clinical immunology and immunopathology. 83(2) |
| ISSN: | 0090-1229 |
| Popis: | The transcription factor NF-kappa B plays a significant role in inflammatory diseases. In this study we have investigated the expression of activated NF-kappa B p65 subunit in the rat adjuvant arthritis model in a 28-day time-course experiment using immunohistochemistry. The expression of p65 was detected in the synovial lining layer and around the blood vessels in the inflamed synovium as early as Day 3 post-adjuvant injection. The cells that expressed p65 in the synovial lining were thought to be macrophage-like synoviocytes. The expression was stronger in the injected hindpaw than that in the noninjected hindpaw. Dexamethasone treatment at 1 mg/kg p.o. (Days 0-20) suppressed both the hindpaw edema and increase in p65 expression. Withdrawal of the treatment caused increases in both p65 expression and paw volume. Together these suggest that activated NF-kappa B was specifically expressed in the arthritic synovium and may play a significant role in the development of arthritis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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