Pharmacokinetics of inhaled [14C]-2-nitropropane in male sprague-dawley rats
| Autor: | S.M. Unger, R.J. Nolan, C.J. Muller |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Inhalation Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Rats Inbred Strains General Medicine Pharmacology Pollution Nitroparaffins Rats Kinetics Propane chemistry.chemical_compound Liver chemistry Pharmacokinetics 2-Nitropropane Alkanes Toxicity Sprague dawley rats Animals Carbon Radioisotopes Rabbits Nitropropane |
| Zdroj: | Ecotoxicology and Environmental Safety. 6:388-397 |
| ISSN: | 0147-6513 |
| DOI: | 10.1016/0147-6513(82)90054-9 |
| Popis: | Rats were exposed by inhalation for 6 hr to 20 or 154 ppm of 2-[ 14 C]nitropropane (2-[ 14 C]NP) and the disposition of radioactivity in these animals was followed for 48 hr. These data indicate that at least 40% of the inhaled 2-[ 14 C]NP was absorbed. 2-[ 14 C]NP was rapidly metabolized and eliminated, and thus has a low potential to accumulate in the rat during prolonged or repeated exposures. Numerous differences were observed in the disposition of 2-[ 14 C]NP at the two exposure concentrations that indicate the kinetics of 2-[ 14 C]NP were nonlinear in rats at the 154 ppm exposure concentration. These changes in the fate of 2-[ 14 C]NP are consistent with and may explain the marked increase in the toxicity observed by others when rats were exposed to high concentrations (≥200 ppm) of 2-nitropropane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|