Particle-size distribution (PSD) of pulverized hair: A quantitative approach of milling efficiency and its correlation with drug extraction efficiency
| Autor: | Silvana Vianna Rodrigues, Eliani Spinelli, Adriana da Silva Barreto, Sorele Batista Fiaux, Aline Garcia da Rosa Chagas |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Narcotics
Diffraction Materials science Scanning electron microscope Analytical chemistry 01 natural sciences Mass Spectrometry Specimen Handling Pathology and Forensic Medicine law.invention 03 medical and health sciences 0302 clinical medicine Cocaine law Humans 030216 legal & forensic medicine Particle Size integumentary system Lasers 010401 analytical chemistry Liquid nitrogen Laser 0104 chemical sciences Substance Abuse Detection Drug extraction Particle-size distribution Microscopy Electron Scanning Ketamine Powders Drug analysis Law Chromatography Liquid Hair |
| Zdroj: | Forensic Science International. 277:188-196 |
| ISSN: | 0379-0738 |
| DOI: | 10.1016/j.forsciint.2017.06.008 |
| Popis: | Different types of hair were submitted to different milling procedures and their resulting powders were analyzed by scanning electron microscopy (SEM) and laser diffraction (LD). SEM results were qualitative whereas LD results were quantitative and accurately characterized the hair powders through their particle size distribution (PSD). Different types of hair were submitted to an optimized milling conditions and their PSD was quite similar. A good correlation was obtained between PSD results and ketamine concentration in a hair sample analyzed by LC-MS/MS. Hair samples were frozen in liquid nitrogen for 5min and pulverized at 25Hz for 10min, resulting in 61% of particles104μm and 39% from 104 to 1000μm. Doing so, a 359% increment on ketamine concentration was obtained for an authentic sample extracted after pulverization comparing with the same sample cut in 1mm fragments. When milling time was extended to 25min,90% of particles were60μm and an additional increment of 52.4% in ketamine content was obtained. PSD is a key feature on analysis of pulverized hair as it can affect the method recovery and reproducibility. In addition, PSD is an important issue on sample retesting and quality control procedures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect