Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
| Autor: | Kumiko Nakagawa, Frank Roesch, Charlotte Hadtstein, Peter Gohlke, Eberhard Ritz, Tobias Odenwald, Claus Peter Schmitt, Franz Schaefer |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Time Factors Calcimimetic Sodium Injections Subcutaneous chemistry.chemical_element Hemodynamics Nephrectomy Sensitivity and Specificity Drug Administration Schedule Rats Sprague-Dawley Renin-Angiotensin System Internal medicine Phenethylamines medicine Animals Circadian rhythm Probability Uremia Aniline Compounds Dose-Response Relationship Drug Propylamines business.industry Blood Pressure Determination General Medicine medicine.disease Rats Dose–response relationship Disease Models Animal Endocrinology Blood pressure chemistry Nephrology Acute Disease Secondary hyperparathyroidism Hypotension business |
| Zdroj: | Journal of the American Society of Nephrology : JASN. 17(3) |
| ISSN: | 1046-6673 |
| Popis: | A previous study in subtotally nephrectomized (SNX) rats suggested beneficial effects of the calcimimetic R-568 beyond the control of mineral metabolism. This study analyzed potential blood pressure (BP)-lowering effects of R-568. Male Sprague-Dawley rats received two-stage subtotal nephrectomy or sham operation. Telemetry devices were inserted into the abdominal aorta, and BP was measured every 5 min. R-568 (20 mg/kg per d) or solvent was infused for 4 wk followed by once-daily subcutaneous injections for 2 wk. Total body sodium was measured by neutron activation analysis. The uremia-induced increase of mean arterial pressure from baseline to day 42 in SNX solvent rats (103+/-5 to 128+/-14 mmHg, P=0.006) was attenuated by R-568 (104+/-5 to 111+/-8 mmHg; P |
| Databáze: | OpenAIRE |
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