Prion diseases and the biosecurity problems
| Autor: | Sergey L. Kalnov, Grebennikova Tv, Nadezhda Yu. Kulikova, Victor A. Zuev |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Prions animal diseases 030106 microbiology Biosecurity Disease Bioinformatics Prion Diseases 03 medical and health sciences Biosafety Virology Animals Humans Effective treatment Medicine Prion protein business.industry Neurodegenerative Diseases General Medicine Containment of Biohazards nervous system diseases Highly sensitive 030104 developmental biology Infectious Diseases Prion Proteins Preclinical stage business |
| Zdroj: | Problems of Virology. 65:71-76 |
| ISSN: | 2411-2097 0507-4088 |
| DOI: | 10.36233/0507-4088-2020-65-2-71-76 |
| Popis: | The review presents the current state of the problem of prions and prion diseases with an emphasis on the epidemiological and epizootological risks of pathogens that cause fatal neurodegenerative diseases in humans and animals. The results of molecular genetic studies of the conversion of normal PrPc prion protein molecules to infectious forms of PrPd, resistance to physical disinfection methods, in particular exceptional thermal stability, and their ability to overcome interspecific barriers, while increasing virulence, are described. The possibility of infection not only by nutrition, when eating even heat-treated meat of sick animals, but also due to surgical interventions, especially neurosurgical and ophthalmic, as well as the use of immunobiological preparations, are emphasized. Since there are currently no means for the effective treatment of prion diseases in the world, attention is drawn to the high degree of relevance for the biosafety of the country to develop domestic highly sensitive test systems that can effectively detect prion infectious protein in vivo at the preclinical stage of the disease. The latest methods of automatic protein amplification and identification of prion proteins are briefly described as the most promising areas of research in the field of diagnosis of prion diseases. |
| Databáze: | OpenAIRE |
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