Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use

Autor: Edna Grünblatt, Kristina Jäger, Katrin H. Preller, Sara L. Kroll, Andrea B. Schote, Boris B. Quednow, Lea M. Hulka, Jobst Meyer, Matthias Vonmoos
Přispěvatelé: University of Zurich, Schote, Andrea B
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Genotype
medicine.medical_treatment
media_common.quotation_subject
Gene Expression
Medicine (miscellaneous)
610 Medicine & health
Psychological Distress
Polymorphism
Single Nucleotide
2738 Psychiatry and Mental Health
Cocaine-Related Disorders
Young Adult
03 medical and health sciences
Receptors
Glucocorticoid
0302 clinical medicine
Glucocorticoid receptor
Internal medicine
medicine
Humans
RNA
Messenger
10064 Neuroscience Center Zurich
Allele
Depression (differential diagnoses)
media_common
Pharmacology
Depression
business.industry
Addiction
Psychiatric assessment
Confounding
Haplotype
2701 Medicine (miscellaneous)
10058 Department of Child and Adolescent Psychiatry
030227 psychiatry
Stimulant
Psychiatry and Mental health
3004 Pharmacology
Endocrinology
Haplotypes
10054 Clinic for Psychiatry
Psychotherapy
and Psychosomatics
Case-Control Studies
Female
business
030217 neurology & neurosurgery
Zdroj: Addiction Biology. 24:730-742
ISSN: 1369-1600
1355-6215
DOI: 10.1111/adb.12632
Popis: Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As the glucocorticoid receptor gene (NR3C1) mediates genomic effects of the stress hormone cortisol, we investigated NR3C1 expression and the association of NR3C1 genotypes with cocaine use, addiction and comorbid psychiatric symptoms in 126 chronic cocaine users and 98 stimulant-naive healthy controls. A comprehensive psychiatric assessment was performed including severity of depressive symptoms and current psychological distress. Whole blood NR3C1 mRNA levels were determined and six NR3C1 polymorphisms (rs10482605, rs41423247, rs10052957, rs6189, rs56149945 and rs6198) were genotyped. Compared to controls, cocaine users showed significantly lower NR3C1 expression (P
Databáze: OpenAIRE
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