Effects of exercise on behavior and peripheral blood lymphocyte apoptosis in a rat model of chronic fatigue syndrome
| Autor: | Jianqi Yuan, Jun Zou, Jiaheng Tu, Shuang Lv |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Rat model Biomedical Engineering Morris water navigation task Apoptosis Lymphocyte apoptosis Biochemistry Biomaterials Rats Sprague-Dawley Internal medicine Physical Conditioning Animal Genetics Chronic fatigue syndrome medicine Animals Animal behavior Lymphocytes Earth-Surface Processes Fatigue Syndrome Chronic Behavior Animal business.industry medicine.disease Tail suspension test Rats Disease Models Animal Endocrinology Peripheral blood lymphocyte Immunology business |
| Zdroj: | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 30(2) |
| ISSN: | 1672-0733 |
| Popis: | This study examined the effects of exercise on behavior and peripheral blood leukocyte apoptosis in a rat model of chronic fatigue syndrome (CFS). Thirty-six healthy male Sprague-Dawley rats were equally randomized into 3 groups: the control group, CFS model group and the exercise group in terms of body weight. A total of 25 rats entered the final statistical analysis due to 11 deaths during the study. CFS model was established by subjecting the rats in CFS model group and exercise group to electric shock, chronic restraint stress and cold water swim. Besides, rats in the exercise group took running wheel exercise. After a week of conditioning feeding, model construction and running wheel exercise were performed simultaneously, and lasted for 23 consecutive days. The behavior experiments, including running wheel exercise, open-field test, tail suspension test and Morris water maze test, were conducted, either before or after the model establishment. Rats were sacrificed and peripheral blood was obtained for the assessment of lymphocyte apoptosis index by flow cytometry (FCM). It was found that as compared with those in the control group, the weight of the rats was decreased obviously (P |
| Databáze: | OpenAIRE |
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