Mechanical, structural and physical aspects of chitosan-based films as antimicrobial dressings
| Autor: | Perfecto Paseiro-Losada, Tomás J. Madera-Santana, Dalia I. Sánchez-Machado, Ana Sanches-Silva, Jaime López-Cervantes, Ana A. Escárcega-Galaz |
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| Rok vydání: | 2018 |
| Předmět: |
Glycerol
Materials science Klebsiella pneumoniae 02 engineering and technology medicine.disease_cause 01 natural sciences Biochemistry Chitosan chemistry.chemical_compound Structural Biology Antimicrobial polymer medicine Molecular Biology Wound Healing biology 010405 organic chemistry Pseudomonas aeruginosa Honey General Medicine equipment and supplies 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial Bandages Anti-Bacterial Agents 0104 chemical sciences Cutaneous ulcers chemistry Chemical engineering Elongation 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 116:472-481 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2018.04.149 |
| Popis: | Chitosan is a biodegradable, non-toxic, and antimicrobial polymer. Chitosan films can be used as a dressing because they promote the healing of cutaneous ulcers. In this study, the mechanical, physical, and microbiological properties films of pure chitosan and films formulated with a glycerol-honey mixture were characterized. The films were smooth, homogenous, transparent, and porous, with no fractures or cracks. Additionally, it was found that all were resistant to breaking, that the tearing force was directly related to the chitosan concentration, and that the addition of honey and glycerol improved the elongation percentage. When evaluating the antimicrobial activity of the films against Pseudomonas aeruginosa and Klebsiella pneumoniae, the films were found to have an effect only by direct contact. In the films formulated with honey, the area of contact increased to 44%. The excellent color, structural, antimicrobial, and surface morphological properties of the newly developed films make them a promising alternative for use as a dressing for the healing of skin ulcers. |
| Databáze: | OpenAIRE |
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