Plasma Lp-PLA2 in acute coronary syndrome: association with major adverse cardiac events in a community-based cohort
| Autor: | Shuiming Gu, Shuijun Li, Ning Li, Chen Yu |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty Coronary artery disease Cohort Studies Risk Factors Tandem Mass Spectrometry Internal medicine medicine Humans Clinical significance Risk factor Acute Coronary Syndrome Aged Community based business.industry Lipoprotein-associated phospholipase A2 General Medicine Middle Aged medicine.disease Prognosis Phospholipases A2 Cohort 1-Alkyl-2-acetylglycerophosphocholine Esterase Cardiology lipids (amino acids peptides and proteins) Female business Mace Biomarkers Chromatography Liquid |
| Zdroj: | Postgraduate medicine. 122(4) |
| ISSN: | 1941-9260 |
| Popis: | Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a useful inflammatory marker of cardiovascular risk, yet there are few reports on the prognostic significance of Lp-PLA2 as a risk factor for acute coronary syndrome (ACS). It is necessary to evaluate the association of Lp-PLA2 with major adverse cardiac events (MACE) in patients with ACS and assess its incremental value for risk discrimination over established risk factors and biomarkers.One hundred fifty-two patients with ACS and 142 patients without coronary artery disease (CAD) from Shanghai Xuhui District, PRC (aged80 years) were enrolled from February 2007 to March 2008 and were followed for a median of 6 months (range, 4-10 months). Plasma Lp-PLA2 activity was measured at baseline with liquid chromatography tandem mass spectrometry. Its clinical significance was evaluated with existing risk indicators.Lp-PLA2 activity was higher in patients with ACS than in patients without CAD (22.36 +/- 1.23 mg/mL vs 19.74 +/- 3.85 mg/mL; P = 0.027). During the follow-up period, 5 cases of cardiovascular death, 8 cases of nonfatal myocardial infarction, and 11 cases of target vessel revascularization occurred. Elevated Lp-PLA2 was associated with an increased risk of MACE (hazard ratio, 1.52; 95% confidence interval, 1.09-2.37; P = 0.033). The Lp-PLA2 activity level in incidental cases was higher than in nonincidental cases (P = 0.04).In this community-based cohort of patients with ACS, Lp-PLA2 was strongly and independently associated with major adverse cardiac events and contributed incrementally to risk discrimination. |
| Databáze: | OpenAIRE |
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